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The Importance of Early Detection of Diabetes Mellitus: Why Timing Matters

By Alpro Pharmacy

October 25, 2024

Key Points:

  • Diabetes mellitus is a chronic condition with high blood sugar, where early detection prevents complications and improves quality of life.

  • Risk factors include obesity, family history, inactivity, and chronic conditions, making regular screening essential.

  • If untreated, diabetes can cause severe complications like nerve damage, heart disease, and infections.

Diabetes mellitus is one of the most common chronic health conditions that affects millions of people on a global scale. It poses significant risks to both individual health and public health systems. Early detection of diabetes mellitus is not just beneficial; it is transformative. It allows for prompt intervention and effective disease management, preventing complications and enhancing overall quality of life. Here, we will explore why it is crucial to identify diabetes early and how this can make a profound difference in health outcomes.

What is Diabetes Mellitus?

Diabetes mellitus involves high blood sugar (hyperglycemia) due to poor glucose use or excess consumption of high-carb foods. Glucose metabolism disorders include impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and overt diabetes.

In Malaysia, 90% of cases are Type 2 Diabetes Mellitus (T2DM), linked to obesity, inactivity, family history, and pregnancy-related diabetes. Similar trends are seen worldwide, driven by modern lifestyles and urbanization.

T2DM is associated with abdominal fat, insulin resistance, and declining pancreatic function. It mainly affects adults, while Type 1 Diabetes (T1DM), an autoimmune condition, is more common in children. This article focuses on T2DM detection and screening.

Early Signs and Late Complications

Early stages of mild diabetes are often asymptomatic, and mild hyperglycemia may progress undiagnosed until classical symptoms start to appear. It is important to detect diabetes early and to initiate management promptly to prevent complications(4).

Common Early Signs of Diabetes:

    • Increased thirst (polydipsia)
    • Increased appetite (polyphagia)
    • Increased urination (polyuria or nocturia – frequent urination at night)
    • Weight loss and muscle atrophy
    • Weight gain (in cases of poorly controlled blood sugar)

Signs of Insulin Resistance:

    • Obesity (especially truncal obesity)
    • Acanthosis nigricans (hyperpigmented, velvety dark patches on skin folds, particularly on the neck, armpits, and groin)

Untreated diabetes can lead to several health issues, mainly vascular complications:

    • Microvascular complications (affect small blood vessels)
    • Macrovascular complications (affect large blood vessels)

These complications are caused by:

    • Inflammation due to high blood sugar (hyperglycemia)
    • Production of superoxide
    • Increased permeability of blood vessels, leading to dysfunction

Comorbidities like high blood pressure and high cholesterol can worsen these problems.

Microvascular diseases can result in severe complications, such as:

    • Retinopathy (eye diseases)
    • Nephropathy (kidney diseases)
    • Neuropathy (nerve diseases)

Common macrovascular complications include heart attacks and strokes, which greatly affect overall health.

High blood sugar can also lead to immune dysfunction, making infections more likely.

Early detection of diabetes can help limit damage, reduce the burden of disease, and encourage healthier lifestyles.

Techniques for Early Detection

In Malaysia, most healthcare personnel are well-versed in managing diabetes and its complications. There is no specific age limit for starting diabetes screening, as even adolescents or young adults at risk may develop diabetes mellitus.

If early signs of diabetes appear, screening should be done before confirmatory tests. Many patients are asymptomatic, but factors like BMI, waist circumference, heart disease, high blood pressure, high cholesterol, endocrine disorders, and chronic medication use can prompt screening.

Screening Criteria as per Malaysian Guidelines

1. Symptomatic individuals

2. Women with a history of gestational diabetes mellitus (GDM)

3. Adults with risk factors (overweight/obese with BMI >23 or increased waist circumference: ≥80 cm for females, ≥90 cm for males) and any of the following conditions:

    • History of heart attack or stroke
    • First-degree relatives with type 2 diabetes (T2DM)
    • High blood pressure
    • High cholesterol
    • History of delivering a large baby (birth weight >4 kg)
    • Physical inactivity or sedentary lifestyle
    • Born to a mother with pregnancy-related diabetes
    • Medical conditions with insulin resistance or on long-term medications

       

4. Prediabetics

      • HbA1c: 5.7–6.2%, IFG, or IGT
      • Require annual testing

5. Adolescents

    • Screen every 3 years if overweight or obese (BMI >85th or >95th percentile) with one or more of the following risks:
      • Family history of T2DM
      • Born to a mother with diabetes
      • Recurrent skin lesions or abscesses
      • Signs of insulin resistance

Screening is usually done via a pinprick test, which is a simple office test. Readings that exceed 5.6 mmol/L for fasting or 7.8 mmol/L for random samples should be referred for confirmatory tests. Although the presence of sugar in urine may also be used to detect early signs of diabetes, contamination or improper collection methods can compromise test results. Therefore, the pinprick test offers better consistency as a diabetes screening method.

Confirmatory tests should be conducted at healthcare facilities under the supervision of qualified healthcare personnel. Diabetes can be confirmed with a fasting blood sugar level, HbA1c level, or through an Oral Glucose Tolerance Test (OGTT).

Fasting Blood Sugar Levels

    • Readings above 7 mmol/L indicate diabetes mellitus.

Random Blood Sugar Levels

      • Readings above 11.1 mmol/L are considered diabetic.

Oral Glucose Tolerance Test (OGTT)

    • Involves taking two blood samples:
      1. Fasting sample
      2. Post-meal sample (2 hours after consuming 75g of glucose).
    • Reference targets:
      • 7 mmol/L for fasting
      • 11.1 mmol/L for post-meal

HbA1c Test

    • Reflects average blood sugar levels over the past three months.
    • Useful for monitoring diabetic control, especially if a patient has trouble completing the OGTT.

While readings above 6.3% generally indicate diabetes mellitus, it is inappropriate to use as a diagnostic test in certain conditions affecting hemoglobin levels, such as anemia, pancreatic disorders, chronic kidney diseases, or in adolescents/teenagers.

Public health initiatives that raise awareness about the risk factors and symptoms of diabetes are essential. Education encourages individuals to seek screening and monitor their health, while community programs and online resources empower them to take charge of their well-being. Implementing lifestyle changes can significantly improve outcomes and reduce complications.

Early detection plays a crucial role in ensuring better long-term health and quality of life. If you have any questions, consult trusted healthcare personnel, as prevention is always better than cure.

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Disclaimer: No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your qualified health professional.

Citations

  1. Clinical Practice Guideline. Management of Type 2 Diabetes Mellitus 6th Edition; Ministry of Health, Malaysia. DECEMBER 2020 MOH/P/PAK/447.20(GU)-e. 
  2. Type 2 Diabetes Mellitus: Practice Essentials, Background, Pathophysiology. eMedicine [Internet]. 2020 Apr 29; Available from: https://emedicine.medscape.com/article/117853-overview#showall
  3. About Diabetes [Internet]. www.nhsinform.scot. Available from: https://www.nhsinform.scot/illnesses-and-conditions/diabetes/diabetes/
  4. National Health Service. Diabetes [Internet]. NHS. 2023. Available from: https://www.nhs.uk/conditions/diabetes/
  5. UFO Themes. Acanthosis nigricans [Internet]. Plastic Surgery Key. 2016 [cited 2024 Oct 21]. Available from: https://plasticsurgerykey.com/acanthosis-nigricans-2/
  6. Altmeyer P. Acanthosis nigricans (overview) [Internet]. Altmeyers.org. Altmeyers Encyclopedia; 2020 [cited 2024 Oct 21]. Available from: https://www.altmeyers.org/en/dermatology/acanthosis-nigricans-overview-118424
  7. What Are the Signs and Symptoms of Type 2 Diabetes? | Everyday Health [Internet]. EverydayHealth.com. Available from: https://www.everydayhealth.com/type-2-diabetes/guide/symptoms/
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